Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications
Qing Xiong1,2, Jie Liu1, Yancheng Xu1
1Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.
Abstract:
With the deepening of the researches on uric acid, especially in the study of metabolic diseases, uric acid has been found to be closely related to obesity, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, and other metabolic diseases. Uric acid causes a series of pathophysiological changes through inflammation, oxidative stress, vascular endothelial injury, and so on and thus subsequently promotes the occurrence and development of diseases. This review confirmed the positive correlation between uric acid and diabetes mellitus and its chronic complications through the pathogenesis and clinical studies aspects.
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