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Meningeal and multiorgan disseminated sporotrichosis: A case report and autopsy study

Helena Duani1, Marina Fernandes Palmerston1, Jésus Faria Rosa Júnior2

  • 1Tropical Medicine and Infectious Diseases Section, Hospital das Clínicas, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Medical Mycology Case Reports
|November 19, 2019
PubMed

Insights

Disseminated sporotrichosis, a fungal infection, can cause severe neurological and systemic complications. This case highlights a fatal outcome despite amphotericin B treatment, emphasizing the aggressive nature of disseminated Sporothrix schenckii infections.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Neurology

Background:

  • Sporotrichosis is a fungal infection typically affecting the skin and lymphatics.
  • Disseminated disease is rare but can involve multiple organ systems.

Observation:

  • A 36-year-old man presented with disseminated sporotrichosis, characterized by seizures and widespread crusted skin lesions.
  • Cerebral imaging revealed an acute ischemic brain event with hemorrhagic transformation.

Findings:

  • Skin biopsy confirmed infection with *Sporothrix schenckii*.
  • Despite treatment with amphotericin B, the patient experienced worsening consciousness, multiorgan failure, and expired.
  • Necropsy confirmed widespread organ involvement, including kidneys, liver, spleen, prostate, testicles, and the central nervous system.

Implications:

  • This case underscores the potential for severe, life-threatening complications in disseminated sporotrichosis.
  • Aggressive fungal infections require prompt diagnosis and potentially novel therapeutic strategies.
  • Widespread organ involvement can lead to rapid clinical deterioration and fatal outcomes.
Keywords:
BrazilEndemic mycosesNecropsySporothrix brasiliensisSporothrix schenckiiSporotrichosis

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