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T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
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Commentary on "Epigenetically Altered T Cells Contribute to Lupus Flares"

Bruce Richardson1

  • 1Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48103-2200, USA.

Journal of Cellular Immunology
|November 19, 2019
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No abstract available in PubMed .

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