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Antibacterial and osteoinductive biomacromolecules composite electrospun fiber
Xuewei Cheng1, Qin Wei2, Yingao Ma1
1College of Chemical Engineering, Xinjiang Normal University, Urumqi 830054, Xinjiang, PR China.
International Journal of Biological Macromolecules
|November 19, 2019
Summary
This study developed novel silver nanoparticle-infused Polylactic acid and Gelatin composite fibers for bone implants. These advanced biomaterials demonstrate excellent antibacterial properties and promote bone healing and blood vessel growth.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Tissue Engineering
Background:
- Bone infections pose a significant challenge to bone regeneration with implants.
- Developing effective anti-infection strategies is crucial for successful bone repair.
Purpose of the Study:
- To create a multifunctional composite fiber with enhanced anti-infection and osseointegration capabilities.
- To investigate the bioactivity, osteoinductivity, and angiogenic potential of silver nanoparticle-modified composite fibers.
Main Methods:
- Co-electrospinning of Polylactic acid (PLLA) and Gelatin (Gel) with silver nanoparticles (Ag-NPs).
- Optimization of PLLA/Gel mass ratio (90:10) and Ag content (7%).
- Evaluation of cell adhesion, proliferation (mesenchymal stem cells, vascular endothelial cells), and antibacterial efficacy.
Main Results:
- Optimized composite fibers exhibited excellent antibacterial rates (>97%) against multiple pathogens.
- Ag-NPs promoted calcium phosphorus nucleation, enhancing osseointegration.
- Composite fibers supported good adhesion and proliferation of bone marrow-derived mesenchymal stem cells and vascular endothelial cells.
Conclusions:
- A novel PLLA/Gel/Ag-NP composite fiber was successfully fabricated.
- The developed biomaterial shows promising bioactivity, osteoinductivity, angiogenic, and antibacterial properties for bone regeneration applications.
