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Updated: Jan 3, 2026
Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
Published on: July 31, 2017
Tumour Regression via Integrative Regulation of Neurological, Inflammatory, and Hypoxic Tumour Microenvironment
Chang Hoon Lee1, Jungsook Cho1, Kyeong Lee1
1College of Pharmacy, Dongguk University, Seoul 04620, Republic of Korea.
Abstract:
Changing trends in anticancer research have altered the treatment paradigm to the extent that it is difficult to investigate any anticancer drugs without mentioning immunotherapy. Thus, we are finally contemplating tumour regression using magic bullets known as immunotherapy drugs. This review explores the possible options and pitfalls in tumour regression by first elucidating the features of cancer and the importance of tumour microenvironments. Next, we evaluated the trends of anticancer therapeutics regulating tumour microenvironment. Finally, we introduced the concept of tumour regression and various targets of tumour microenvironment, which can be used in combination with current immunotherapy for tumour regression. In particular, we emphasize the importance of regulating the neurological manifestations of tumour microenvironment (N) in addition to inflammation (I) and hypoxia (H) in cancer.
Insights
Immunotherapy drugs offer new hope for cancer treatment by targeting the tumor microenvironment. This review highlights strategies for tumor regression, emphasizing the role of neurological, inflammatory, and hypoxic factors.
Area of Science:
- Oncology
- Immunology
- Cancer Research
Background:
- Anticancer research has shifted towards immunotherapy.
- Tumor microenvironment plays a critical role in cancer progression and treatment response.
- Investigating novel therapeutic strategies for tumor regression is essential.
Purpose of the Study:
- To explore options and challenges in achieving tumor regression using immunotherapy.
- To review current anticancer therapeutics that modulate the tumor microenvironment.
- To introduce targets within the tumor microenvironment for combination immunotherapy.
Main Methods:
- Literature review of cancer features and tumor microenvironment.
- Evaluation of anticancer therapeutics regulating the tumor microenvironment.
- Identification of tumor microenvironment targets for immunotherapy combinations.
Main Results:
- The tumor microenvironment significantly influences immunotherapy efficacy.
- Specific targets within the tumor microenvironment can be leveraged for enhanced tumor regression.
- Regulating neurological manifestations (N), inflammation (I), and hypoxia (H) are key strategies.
Conclusions:
- Immunotherapy holds significant promise for tumor regression.
- Combination therapies targeting the tumor microenvironment, including neurological, inflammatory, and hypoxic aspects, are crucial for effective cancer treatment.
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