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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.1K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.0K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.0K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.3K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.3K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

3.0K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.0K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

1.7K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
1.7K

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Related Experiment Video

Updated: Jan 3, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Lung Microbiome in Asthma: Current Perspectives.

Konstantinos Loverdos1, Georgios Bellos2, Louiza Kokolatou2

  • 1ICU, 1st Department of Pulmonary Medicine, "Sotiria" Hospital; Athens School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Journal of Clinical Medicine
|November 20, 2019
PubMed
Summary
This summary is machine-generated.

The human microbiome influences chronic respiratory diseases like asthma. Understanding lung microbiota and the lung-gut axis may lead to new prevention and treatment strategies.

Keywords:
asthmaimmune responsesinflammationmicrobiomepathogenesis

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Area of Science:

  • Microbiology
  • Immunology
  • Pulmonology

Background:

  • The human microbiome plays a role in chronic respiratory diseases, especially airway conditions.
  • Evidence suggests the lung microbiome, including bacteria, is involved in disease pathogenesis.
  • The interaction between the lung microbiota and the host immune system is crucial.

Purpose of the Study:

  • To review current evidence on lung microbiome characteristics.
  • To explore the lung-gut axis and its role in asthma pathogenesis.
  • To investigate therapeutic microbiome manipulation for asthma prevention and treatment.

Main Methods:

  • Literature review of existing studies on lung microbiome and asthma.
  • Analysis of host-microbiota interactions and immune system responses.
  • Exploration of potential therapeutic strategies targeting the microbiome.

Main Results:

  • The lung microbiome, particularly the bacteriome, exhibits distinct characteristics.
  • The lung-gut axis significantly influences asthma pathogenesis.
  • Microbiome interactions with the immune system are key to disease development.

Conclusions:

  • The lung microbiome is a significant factor in chronic respiratory diseases.
  • Targeting the lung-gut axis and microbiome modulation offers potential for asthma management.
  • Further research into microbiome-based therapies is warranted for asthma prevention and treatment.