Fat Grafting for Facial Rejuvenation through Injectable Tissue Replacement and Regeneration: A Differential,...

Injectable tissue replacement and regeneration (ITR²) is a standardized fat grafting technique, which anatomically addresses losses of facial volume, laxity, and sun damage of the skin resulting from the natural processes of aging. Based on the structural differences of fat existing in the deeper versus the superficial fat compartments of the face, while accounting for skeletal losses and skin aging, ITR² utilizes 3 sizes of fat grafts-millifat (parcel size 2.0-2.5 mm), microfat (1.0 mm), and nanofat (<500 μm)-to replicate characteristics of fat cells lost with facial decay and provide increased blood supply and improvements in aging skin.