Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Niacin maculopathy.

R H Millay1, M L Klein, D R Illingworth

  • 1Department of Ophthalmology, Virginia Mason Medical Center, Seattle, WA 98111.

Ophthalmology
|July 1, 1988
PubMed
Summary
This summary is machine-generated.

High doses of niacin can cause reversible cystoid maculopathy. Ophthalmologic evaluation is recommended only for patients experiencing visual symptoms while taking niacin.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The antibody-peptide fusion protein, AT-02, is an effective opsonin with pan-amyloid reactivity.

npj drug discovery·2026
Same author

Proton transfer drives protein radical formation in Helicobacter pylori catalase but not in Penicillium vitale catalase.

Journal of the American Chemical Society·2011
Same author

Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.

Genes and immunity·2010
Same author

Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss.

Journal of medical genetics·2008
Same author

X-ray diffraction and computation yield the structure of alkanethiols on gold(111).

Science (New York, N.Y.)·2008
Same author

Genetic and phenotypic heterogeneity in pattern dystrophy.

The British journal of ophthalmology·2005

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Toxicology

Background:

  • High-dose niacin (nicotinic acid) is used to treat hypercholesterolemia.
  • Niacin can cause various side effects, including visual disturbances.

Observation:

  • Three patients developed cystoid maculopathy without leakage on fluorescein angiography.
  • A fourth patient experienced symptom resolution upon niacin discontinuation.
  • Fifteen asymptomatic patients on high-dose niacin showed no subclinical macular disease.

Findings:

  • Niacin-induced toxic cystoid maculopathy is a reversible condition.
  • This condition affects approximately 0.67% of patients on high-dose niacin.
  • Macular changes were observed only in patients with concurrent visual symptoms.

Related Experiment Videos

Implications:

  • Ophthalmologic evaluation is warranted for patients experiencing visual symptoms while on high-dose niacin.
  • Routine screening for subclinical macular disease in asymptomatic patients is not necessary.
  • Understanding niacin's ocular toxicity is crucial for patient management.