Periradicular lymphoma: differentiation from inflammation

Although endodontists concern themselves primarily with inflammatory disease, constant vigilance should be maintained so that the diagnosis of periradicular malignant disease is not delayed. This article reviews oral lymphoma and presents two cases that illustrate the difficulty that can be encountered in establishing a timely and accurate diagnosis. Suggestions for maximizing the chances of early differentiation of inflammatory from malignant disease are presented. The role of the biopsy and its limitations are offered.