Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

1.6K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.6K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.5K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.5K
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

2.7K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ageing stress signalling: metastatic plasticity and metabolic vulnerability in lung cancer.

Signal transduction and targeted therapy·2026
Same author

Retraction Note: Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells.

Experimental & molecular medicine·2026
Same author

Detection of atrial fibrillation via adhesive single-lead ECG vs. Holter monitoring in embolic stroke of undetermined source: the AVANT-GARDE trial.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2026
Same author

Therapeutic Effects of Fermented Soy Extract on Osteoporotic Changes in Ovariectomized Mice as a Model of Menopause.

Molecular nutrition & food research·2026
Same author

Angelic Acid Disassembles Fibrillar α-Synuclein Aggregates through β-Sheet Interface Disruption.

ACS chemical neuroscience·2026
Same author

Ethyl acetate extract of Lactococcus lactis KR-050L suppresses IL-6/STAT3 signaling in Hep3B cells and alleviates DSS-induced colitis in mice.

Journal of biotechnology·2026

Related Experiment Video

Updated: Jan 3, 2026

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

2.2K

Models of multiple system atrophy.

He-Jin Lee1,2,3, Diadem Ricarte4, Darlene Ortiz4

  • 1Department of Anatomy, School of Medicine, Konkuk University, 120 Neungdong-Ro, Gwangjin-gu, Seoul, 05029, South Korea. hjlee@kku.ac.kr.

Experimental & Molecular Medicine
|November 20, 2019
PubMed
Summary

Multiple system atrophy (MSA) research is advancing through new models. This review covers toxicant-induced, α-synuclein models, and transmission models to understand MSA pathogenesis.

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.9K
Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
09:46

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

5.1K

Related Experiment Videos

Last Updated: Jan 3, 2026

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

2.2K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.9K
Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
09:46

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

5.1K

Area of Science:

  • Neurodegenerative diseases
  • α-synucleinopathies
  • Neurobiology

Background:

  • Multiple system atrophy (MSA) is a rare neurodegenerative disorder characterized by parkinsonism, cerebellar syndrome, and autonomic failure.
  • Pathologically, MSA involves glial cytoplasmic inclusions of α-synuclein in oligodendrocytes, classifying it as an α-synucleinopathy.
  • Research into MSA pathogenesis lags behind other synucleinopathies like Parkinson's disease.

Purpose of the Study:

  • To review and analyze existing cellular and animal models for studying Multiple system atrophy (MSA).
  • To discuss advancements in MSA research driven by novel model systems.
  • To evaluate the strengths and limitations of current MSA models and suggest future research directions.

Main Methods:

  • Review of toxicant-induced animal models of MSA.
  • Analysis of α-synuclein-overexpressing cellular models.
  • Examination of oligodendrocyte-specific α-synuclein mouse models.
  • Discussion of findings from transmission mouse models using MSA brain extracts.

Main Results:

  • Various models, including transgenic and transmission models, are crucial for understanding MSA.
  • These models have facilitated significant advancements in comprehending MSA pathogenesis.
  • The review highlights the utility and constraints of each model system.

Conclusions:

  • Current models provide valuable insights into Multiple system atrophy (MSA) mechanisms.
  • Further development of robust and predictive MSA models is essential for therapeutic advancements.
  • This review guides future research by identifying model system strengths and weaknesses.