Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

247
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
247

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevention and treatment of incontinence-associated dermatitis through optimising care: the PREVENT-IAD Synopsis.

Health technology assessment (Winchester, England)·2026
Same author

A Benchtop Evaluation of Cervical Collar Design and Strap Tension.

Medical devices (Auckland, N.Z.)·2026
Same author

A novel approach to characterize the energy cost of human cool-seeking behavior and its individual variability during heat stress.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
Same author

Evidence-Generated Sockets for Transtibial Prosthetic Limbs Compared With Conventional Computer-Aided Designs: A Multiple-Methods Study From the Patient's Perspective.

JMIR rehabilitation and assistive technologies·2025
Same author

Repeated Pressure and Shear Stress at the Posterior Heel Following Localized Skin Cooling: Protocol for a Repeated Measures Cohort Study.

JMIR research protocols·2025
Same author

A Randomised Cross-Over Study to Evaluate the Physiological Effects of Internal Air Pressure Changes in Advanced Support Surface Design.

International wound journal·2025
Same journal

A multi-fidelity poroelastic finite element and machine learning framework for characterizing respiratory mechanics in porcine lungs.

Biomechanics and modeling in mechanobiology·2026
Same journal

Mechanics and mechanobiology of arterial development.

Biomechanics and modeling in mechanobiology·2026
Same journal

Mechanics-driven emergence of mesenchymal migration features.

Biomechanics and modeling in mechanobiology·2026
Same journal

Parameter estimation in blood flow models from highly undersampled k-space magnetic resonance imaging data.

Biomechanics and modeling in mechanobiology·2026
Same journal

Integrating serial block-face SEM with voxel-based finite element analysis for high-fidelity micromechanical modelling of anisotropic soft tissues: application to human dermis.

Biomechanics and modeling in mechanobiology·2026
Same journal

Stresses and fluid flow in lamina cribrosa through anisotropic poroelasticity.

Biomechanics and modeling in mechanobiology·2026
See all related articles

Related Experiment Video

Updated: Jan 3, 2026

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees
14:31

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees

Published on: July 15, 2009

14.4K

Predictive prosthetic socket design: part 2-generating person-specific candidate designs using multi-objective

J W Steer1, P A Grudniewski1, M Browne1

  • 1Faculty of Engineering and Physical Sciences, University of Southampton, Southampton, UK.

Biomechanics and Modeling in Mechanobiology
|November 20, 2019
PubMed
Summary
This summary is machine-generated.

This study introduces advanced shape optimization methods for prosthetic sockets, improving fit and reducing design time for amputees. These computational tools assist prosthetists in creating better-fitting prosthetic limbs faster.

Keywords:
AmputationFEAOptimisationResidual limb

More Related Videos

A Structured Rehabilitation Protocol for Improved Multifunctional Prosthetic Control: A Case Study
06:58

A Structured Rehabilitation Protocol for Improved Multifunctional Prosthetic Control: A Case Study

Published on: November 6, 2015

10.1K
Author Spotlight: Streamlined Brain and Skull Modeling for Enhanced Neurosurgical Planning in NHP Research
06:33

Author Spotlight: Streamlined Brain and Skull Modeling for Enhanced Neurosurgical Planning in NHP Research

Published on: February 9, 2024

1.7K

Related Experiment Videos

Last Updated: Jan 3, 2026

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees
14:31

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees

Published on: July 15, 2009

14.4K
A Structured Rehabilitation Protocol for Improved Multifunctional Prosthetic Control: A Case Study
06:58

A Structured Rehabilitation Protocol for Improved Multifunctional Prosthetic Control: A Case Study

Published on: November 6, 2015

10.1K
Author Spotlight: Streamlined Brain and Skull Modeling for Enhanced Neurosurgical Planning in NHP Research
06:33

Author Spotlight: Streamlined Brain and Skull Modeling for Enhanced Neurosurgical Planning in NHP Research

Published on: February 9, 2024

1.7K

Area of Science:

  • Biomedical Engineering
  • Rehabilitation Technology
  • Computational Design

Background:

  • Prosthetic socket design is crucial for post-amputation rehabilitation and ambulation.
  • Current custom socket design is time-consuming, requiring expert knowledge for optimal fit.
  • There is a need for rapid, accurate methods to produce personalised prosthetic devices.

Purpose of the Study:

  • To present candidate shape optimization methods for prosthetic socket design.
  • To leverage numerical optimization, surrogate modeling, and evolutionary computation for improved socket fitting.
  • To reduce the time spent on early-stage socket design, allowing prosthetists to focus on fine-tuning.

Main Methods:

  • Application of numerical optimization techniques to prosthetic socket design.
  • Integration of surrogate modeling and evolutionary computation for shape optimization.
  • Analysis of pressure distribution on the residual limb for optimized load transfer.

Main Results:

  • Developed a series of prosthetic socket designs with preferential loading/unloading of residual limb regions.
  • Achieved significant pressure differences (up to 31 kPa over fibula head, 14 kPa over residuum tip).
  • Demonstrated a spectrum of designs between established patellar tendon bearing (PTB) and total surface bearing (TSB) approaches.

Conclusions:

  • Proposed computational methods can significantly aid prosthetists in designing better-fitting sockets.
  • These methods offer a valuable tool to accelerate the early stages of socket design.
  • The approach complements, rather than replaces, the prosthetist's expertise and client interaction.