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Arterial Hypertension, Aldosterone, and Atrial Fibrillation

Teresa M Seccia1, Brasilina Caroccia1, Giuseppe Maiolino1

  • 1Clinica dell'Ipertensione Arteriosa, Department of Medicine-DIMED, University of Padua, Via Giustiniani, 2, 35128, Padova, Italy.

Current Hypertension Reports
|November 20, 2019
PubMed

Insights

High aldosterone may contribute to atrial fibrillation (AF), the most common heart rhythm disorder. Understanding this link is crucial for managing hypertensive patients with AF.

Area of Science:

  • Cardiology
  • Endocrinology

Background:

  • Atrial fibrillation (AF) is a prevalent arrhythmia, increasing healthcare burden due to aging populations.
  • AF is associated with heart failure, hospitalization, and requires lifelong treatment.
  • Identifying predisposing factors for AF is critical for effective management.

Purpose of the Study:

  • To review evidence linking hyperaldosteronism to atrial fibrillation.
  • To discuss the implications of this link for managing hypertensive patients with AF.

Main Methods:

  • Review of experimental data and clinical evidence.
  • Analysis of conditions with high aldosterone levels, including primary aldosteronism and resistant hypertension.

Main Results:

  • Hyperaldosteronism can cause significant target organ damage, particularly in the heart, vasculature, and kidneys.
  • Evidence supports a connection between elevated aldosterone and the occurrence of atrial fibrillation.

Conclusions:

  • Hyperaldosteronism is a potential contributor to atrial fibrillation.
  • Management strategies for hypertensive patients with AF should consider aldosterone levels.
Abstract

Keywords:
AldosteroneArrhythmiaAtrial fibrillationHypertension

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