Long noncoding RNAs: emerging roles in pulmonary hypertension

Area of Science:

• Molecular Biology
• Genetics
• Cardiovascular Research

Background:

• Pulmonary hypertension (PH) is a progressive disease with poor prognosis, involving complex vascular remodeling.
• The precise molecular mechanisms underlying PH pathogenesis remain largely unclear.
• Long noncoding RNAs (lncRNAs) are emerging as critical epigenetic regulators in various biological processes, including vascular diseases.

Purpose of the Study:

• To review the types, biogenesis, and biological functions of lncRNAs in vascular diseases.
• To summarize known and potential lncRNAs involved in the onset and development of PH.
• To explore the interaction between lncRNAs and microRNAs (miRNAs) in PH and discuss their therapeutic potential.

Main Methods:

• Literature review of studies on lncRNAs and PH.
• Analysis of lncRNA biogenesis and epigenetic modification roles.
• Examination of lncRNA-miRNA interactions in the context of PH.

Main Results:

• lncRNAs play crucial roles in the epigenetic regulation of vascular remodeling in PH.
• Several lncRNAs have been identified as involved in PH, with more potential candidates highlighted.
• lncRNA-miRNA interactions are significant in PH development and progression.

Conclusions:

• lncRNAs are vital regulators of pulmonary hypertension.
• lncRNAs represent promising diagnostic biomarkers for PH.
• lncRNAs offer potential therapeutic targets for managing PH.