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Updated: Jan 3, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Meroterpenoids and alkaloids from Ganoderma australe
Jiao-Jiao Zhang1,2, Yun Dong1,3, Fu-Ying Qin1,2
1School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen, PR China.
Abstract:
Two new mertoterpenoids, australins A (1) and B (2), and a new alkaloid, australine (4), together with five known compounds (3, 5-8) were isolated from the fruiting bodies of Ganoderma australe. Their structures including absolute configurations were assigned by using spectroscopic methods and electronic circular dichroism (ECD) calculations. Racemic australin A was further purified by chiral HPLC. Biological assessments reveal that compounds (+)-1 and 7 could significantly protect SH-SY5Y cells from glutamate-induced neural excitotoxicity.
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