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Preventing and Treating Heart Failure with Sodium-Glucose Co-Transporter 2 Inhibitors.
Muthiah Vaduganathan1, James L Januzzi2
1Brigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, Boston, Mass.
The American Journal of Cardiology
|November 20, 2019
Summary
Sodium-glucose co-transporter 2 (SGLT2) inhibitors effectively reduce heart failure events in type 2 diabetes patients. This therapy offers a new approach for preventing heart failure in at-risk individuals.
Area of Science:
- Cardiology
- Endocrinology
- Nephrology
Background:
- Heart failure is a significant complication in type 2 diabetes mellitus (T2DM), increasing morbidity and mortality.
- Limited therapeutic options previously existed to mitigate this excess risk.
- Sodium-glucose co-transporter 2 (SGLT2) inhibitors offer novel multisystem health benefits.
Purpose of the Study:
- To evaluate the efficacy of SGLT2 inhibitors in reducing heart failure events in patients with T2DM.
- To explore the role of SGLT2 inhibitors in preventing heart failure in at-risk populations.
- To assess the potential of SGLT2 inhibitors in treating heart failure.
Main Methods:
- Analysis of three large cardiovascular outcomes trials involving patients with T2DM and atherosclerotic cardiovascular disease.
- Review of a trial demonstrating canagliflozin's effect on heart failure events in T2DM patients with albuminuric chronic kidney disease.
Main Results:
- Consistent reductions in heart failure events observed across multiple trials with SGLT2 inhibitors.
- Significant reduction in heart failure events shown by canagliflozin in T2DM patients with albuminuric chronic kidney disease.
Conclusions:
- SGLT2 inhibitors represent a crucial new therapeutic strategy for preventing heart failure in T2DM patients.
- Ongoing research is investigating SGLT2 inhibitors for treating heart failure in broader patient populations, including those without T2DM.
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