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Related Experiment Videos

Morphine and ibuprofen compared using the cold pressor test.

S F Jones1, H J McQuay, R A Moore

  • 1Oxford Regional Pain Relief Unit and Nuffield Department of Anaesthetics, OxfordU.K. DPC European Research Institute, Witney, OxonU.K.

Pain
|August 1, 1988
PubMed
Summary
This summary is machine-generated.

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This study found that morphine effectively reduced pain in the cold pressor model, while ibuprofen did not. This highlights morphine

Area of Science:

  • Pharmacology
  • Pain Management
  • Clinical Trials

Background:

  • The cold pressor test is a validated model for evaluating analgesic efficacy.
  • Understanding the differential effects of opioids and non-steroidal anti-inflammatory drugs (NSAIDs) is crucial for pain management.

Purpose of the Study:

  • To compare the analgesic efficacy of oral morphine sulphate and ibuprofen in a human experimental pain model.
  • To investigate the correlation between plasma drug concentrations and analgesic effects.

Main Methods:

  • A double-blind, double-dummy, placebo-controlled study involving 12 healthy volunteers.
  • Administration of single oral doses of morphine sulphate (10 mg) or ibuprofen (600 mg) against a placebo.
  • Pain intensity was measured at multiple time points using the cold pressor test; plasma samples were analyzed for drug metabolites.

Related Experiment Videos

Main Results:

  • Morphine significantly reduced pain intensity and increased pain threshold compared to placebo.
  • Ibuprofen showed no significant analgesic effect compared to placebo.
  • A significant correlation was observed between plasma morphine concentrations and analgesic effect.

Conclusions:

  • The cold pressor model is sensitive to opioid analgesia (morphine) but insensitive to NSAIDs (ibuprofen).
  • This study validates the cold pressor model for assessing opioid efficacy and supports the use of morphine for acute pain management.