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Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes
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Temperature effect on memristive ion channels.

Ying Xu1, Jun Ma2,3,4, Xuan Zhan1

  • 11Department of Physics, Central China Normal University, Wuhan, 430079 China.

Cognitive Neurodynamics
|November 20, 2019
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Summary

Neural electrical activity depends on temperature, which modulates ion channel behavior. This study models ion channels as memristors, revealing temperature

Keywords:
Ion channelsMemristorPatch temperaturePinched hysteresis loop

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Area of Science:

  • Neuroscience
  • Biophysics
  • Computational Biology

Background:

  • Neuron electrical activity is sensitive to membrane patch temperature.
  • Temperature influences ion channel gating kinetics, affecting neuronal function.
  • Memristor physics offers a novel framework for modeling ion channel behavior.

Purpose of the Study:

  • To investigate the role of temperature in modulating neuronal electrical activity.
  • To model ion channels as memristors and analyze their temperature-dependent characteristics.
  • To explore the combined effects of temperature and external stimuli on neuronal activity modes.

Main Methods:

  • Utilized memristor-based voltage gate variables to model potassium and sodium ion channels.
  • Applied external stimuli to observe electrical activity under varying patch temperatures.
  • Analyzed memristor hysteresis loops and conductance amplitudes as a function of temperature and frequency.

Main Results:

  • Ion channels exhibit memristive behavior, with hysteresis loop shape dependent on voltage and temperature.
  • Increasing patch temperature enlarges memristor hysteresis loops for ion channels.
  • Excitation frequency and temperature interact to influence hysteresis lobe area and conductance amplitude.

Conclusions:

  • Ion channels can be effectively modeled as physical memristors.
  • Memristive properties of ion channels are significantly modulated by temperature.
  • Temperature and external stimuli are crucial factors for controlling neuronal activity modes.