Kimura's Disease: A Diagnostic and Therapeutic Challenge

Area of Science:

• Otorhinolaryngology
• Pathology
• Immunology

Background:

• Kimura's disease, or Eosinophilic Granuloma, is a rare chronic inflammatory condition.
• It primarily affects the Oriental population, presenting with subcutaneous nodules, lymphadenopathy, and salivary gland issues.
• The etiology of Kimura's disease remains largely unknown, with rare instances of renal involvement.

Purpose of the Study:

• To present a case series of two patients diagnosed with Kimura's disease.
• To illustrate the diagnostic and management approaches for Kimura's disease presenting as head and neck swellings.

Main Methods:

• Two case studies of patients with Kimura's disease were analyzed.
• Diagnostic methods included clinical presentation, imaging, and histopathological examination of excisional biopsies.
• Surgical excision (Superficial Parotidectomy with lymph node excision) was performed for both patients.

Main Results:

• The first case involved a middle-aged female with a parotid swelling and lymphadenopathy, confirmed as Kimura's disease post-biopsy.
• The second case involved a young adult with a post-auricular swelling, also diagnosed as Kimura's disease via excision biopsy.
• Both patients achieved disease-free status at 1 year and 8 months post-treatment.

Conclusions:

• Surgical excision and histopathological examination are crucial for diagnosing Kimura's disease.
• Kimura's disease, even when presenting as neoplasms, can be effectively managed with surgical intervention.
• The case series demonstrates successful outcomes for Kimura's disease patients treated with excision biopsy.