Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antibiotic Selection

Antibiotic Selection

Combined Effects of Drugs: Synergism

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...

Development of Antibiotic Resistance

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...

Standard Precaution

Standard Precaution

Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...

Biological Methods for Microbial Control

Biological Methods for Microbial Control

Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Gross anatomy of vascular supply and drainage of mammary fat pads in mice models.

Anatomia, histologia, embryologia·2024

Same author

A rare case of non secretory multiple myeloma.

The Journal of the Association of Physicians of India·2020

Same author

Basidiobolomycosis - Miss Me; It Hurts You.

The Journal of the Association of Physicians of India·2019

Same author

Prevalence of bovine microfilariasis in Rayalaseema region of Andhra Pradesh.

Journal of parasitic diseases : official organ of the Indian Society for Parasitology·2017

Same author

Microwave-assisted extraction of pectic polysaccharide from waste mango peel.

Carbohydrate polymers·2015

Same author

When molecular diagnosis went wrong.

Indian journal of pathology & microbiology·2011

Search research articles

Related Experiment Video

Updated: Jan 3, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Restricting high-end antibiotics usage - challenge accepted!

J Jayalakshmi¹, M S Priyadharshini¹

¹Department of Microbiology, P.S.G. Institute of Medical, Sciences and Research, Coimbatore, Tamil Nadu, India.

Journal of Family Medicine and Primary Care

|November 20, 2019

Summary

Judicious use of high-end antibiotics improved significantly after educational interventions, reducing unjustified prescriptions by 51.2%. This highlights the importance of antimicrobial stewardship for better patient outcomes and combating resistance.

Keywords:

Antibiotics antimicrobial resistance antimicrobial stewardship audit restricted antibiotics usage

More Related Videos

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

Published on: July 21, 2023

Related Experiment Videos

Last Updated: Jan 3, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

Published on: July 21, 2023

Area of Science:

Infectious Diseases
Clinical Pharmacy
Hospital Administration

Background:

Antimicrobial resistance (AMR) poses a significant threat, increasing morbidity, mortality, and healthcare costs.
The misuse of antimicrobials accelerates the development of AMR.
Antimicrobial stewardship programs, including preauthorization and restricted use of high-end antibiotics, are crucial for managing AMR.

Purpose of the Study:

To assess the judicious usage of high-end antibiotics in hospitalized patients.
To evaluate the impact of educational interventions on antibiotic prescribing practices.

Main Methods:

A prospective observational study was conducted over three months.
Data on high-end antibiotic usage were collected using a structured proforma.
Department-wise educational interventions and feedback were provided, followed by reassessment.

Main Results:

Meropenem was the most frequently used high-end antibiotic.
Educational interventions led to a 51.2% reduction in unjustified antibiotic usage.
The appropriateness of antibiotic usage increased from 77% pre-intervention to 88% post-intervention.

Conclusions:

Sustained compliance with judicious high-end antibiotic use is essential.
Continuous strengthening of antimicrobial stewardship practices is critical for combating AMR.