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The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

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Updated: Jan 3, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Melanoma-associated retinopathy.

S Elsheikh¹, S P Gurney¹, M A Burdon¹

¹Birmingham Neuro-Ophthalmology, Queen Elizabeth Hospital, University Hospitals Birmingham, Birmingham, UK.

Clinical and Experimental Dermatology

|November 20, 2019

Summary

This summary is machine-generated.

Melanoma-associated retinopathy (MAR) is a rare autoimmune condition linked to melanoma. Early detection and treatment of MAR can improve visual outcomes and prevent irreversible retinal damage.

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Area of Science:

Ophthalmology
Oncology
Immunology

Background:

Melanoma-associated retinopathy (MAR) is a rare paraneoplastic autoimmune disorder.
It is associated with cutaneous malignant melanoma.
MAR significantly impacts patient quality of life due to visual disturbances.

Purpose of the Study:

To raise awareness of Melanoma-associated retinopathy (MAR).
To present the latest evidence on the investigation and management of MAR.
To highlight the prognostic significance of early MAR recognition.

Main Methods:

This is a review article.
The authors synthesized current evidence on MAR.
Focus on clinical presentation, diagnosis, and treatment strategies.

Main Results:

MAR presents with acute night blindness, visual phenomena, and visual field defects.
Early recognition of MAR can precede melanoma diagnosis.
Prompt treatment may prevent irreversible retinal damage and improve vision.

Conclusions:

MAR is a critical, though rare, paraneoplastic syndrome.
Awareness and timely intervention are key for better patient outcomes.
Further research into optimal management strategies is warranted.