Related Experiment Video

Updated: Jan 3, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.0K

Isolated low levels of high-density lipoprotein cholesterol and stroke incidence: JMS Cohort Study

Jun Watanabe1, Eiichi Kakehi2, Kazuhiko Kotani1

  • 1Center for Community Medicine, Jichi Medical University, Shimotsuke, Japan.

Journal of Clinical Laboratory Analysis
|November 20, 2019
PubMed

Insights

Isolated low high-density lipoprotein cholesterol (HDL-C) does not predict stroke incidence. Low HDL-C combined with other dyslipidemias may increase stroke risk.

Area of Science:

  • Cardiovascular epidemiology
  • Neurology
  • Metabolic disorders

Background:

  • The role of isolated low high-density lipoprotein cholesterol (HDL-C) in stroke incidence remains unclear.
  • Stroke is a leading cause of long-term disability, making stroke incidence a critical research area.
  • Previous studies linked isolated low HDL-C to stroke mortality, but not incidence.

Purpose of the Study:

  • To investigate whether isolated low HDL-C levels predict the incidence of first-ever stroke.
  • To determine the association between non-isolated low HDL-C and stroke incidence.

Main Methods:

  • A cohort study involving 11,025 community residents without prior stroke history.
  • Analysis using Cox regression models to calculate Hazard Ratios (HRs) for isolated and non-isolated low HDL-C.
  • Comparison of low HDL-C levels against normal HDL-C levels in relation to stroke incidence.

Main Results:

  • Over a 10.7-year follow-up, 412 residents experienced their first stroke.
  • The multivariable-adjusted HR for isolated low HDL-C was 1.11 (95% CI, 0.85-1.44).
  • The multivariable-adjusted HR for non-isolated low HDL-C was 1.35 (95% CI, 1.01-1.81).

Conclusions:

  • Isolated low HDL-C levels are not a significant predictor of stroke incidence.
  • Low HDL-C in conjunction with other dyslipidemias may contribute to stroke incidence.
  • Findings suggest that the presence of other lipid abnormalities is crucial for low HDL-C to impact stroke risk.
Abstract

Keywords:
Japanesecohort studieshigh-density lipoproteinincidencestroke

More Related Videos

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.7K

Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
2.7K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
285
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
528
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.2K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
408
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.3K