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Prognostic significance of left ventricular end diastolic pressure using E/E' in patients with hypertrophic

Hala Mahfouz Badran1,2, Ghada Soltan1, Reda Almeleigi1

  • 1Cardiology Department, Menoufia University, Tanta, Egypt.

Echocardiography (Mount Kisco, N.Y.)
|November 20, 2019
PubMed

Insights

The E/e

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiovascular Disease

Background:

  • Left ventricular (LV) diastolic dysfunction is a key characteristic of hypertrophic cardiomyopathy (HCM).
  • The E/e' ratio, derived from early diastolic transmitral flow and mitral annular velocity, accurately predicts LV filling pressure.

Purpose of the Study:

  • To evaluate the predictive value of the E/e' ratio for cardiovascular mortality in patients with HCM.
  • To identify independent predictors of mortality in HCM patients.

Main Methods:

  • Echocardiographic E/e' measurements were performed in 243 HCM patients.
  • Data included clinical evaluation, conventional echocardiography, cardiopulmonary exercise testing, and Holter monitoring.
  • Multivariate analysis was used to determine independent predictors of mortality.

Main Results:

  • During a mean follow-up of 3.2 years, 7% of patients died.
  • Non-survivors exhibited higher E/e' ratios, LVOTO gradients, and restrictive filling patterns.
  • The E/e' ratio and LVOTO gradient were identified as independent predictors of all-cause mortality in HCM.

Conclusions:

  • The E/e' ratio is a potent predictor of mortality in hypertrophic cardiomyopathy.
  • The predictive power of E/e' is enhanced when associated with left ventricular outflow tract (LVOT) obstruction.
Abstract

Keywords:
E/Ediastolic functionhypertrophic cardiomyopathy

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