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Updated: Jan 3, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Recent Advances of the Halogen-Zinc Exchange Reaction
Moritz Balkenhohl1, Paul Knochel1
1Department Chemie und Pharmazie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377, München, Germany.
Abstract:
For the preparation of zinc organometallics bearing highly sensitive functional groups such as ketones, aldehydes or nitro groups, especially mild halogen-zinc exchange reagents have proven to be of great potential. In this Minireview, the latest research in the area of the halogen-zinc exchange reaction is reported, with a special focus lying on novel dialkylzinc reagents complexed with lithium alkoxides. Additionally, the preparation and application of organofluorine zinc reagents and transition-metal-catalyzed halogen-zinc exchange reactions are reviewed.
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