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Robust outer volume suppression utilizing elliptical pulsed second order fields (ECLIPSE) for human brain proton

Chathura Kumaragamage1, Henk M De Feyter1, Peter Brown1

  • 1Department of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut.

Magnetic Resonance in Medicine
|November 20, 2019
PubMed
Summary
This summary is machine-generated.

Novel lipid suppression sequences using ECLIPSE technology significantly improve proton MRSI in the brain. This method offers robust extracranial lipid suppression with reduced radiofrequency power, enhancing image quality.

Keywords:
ECLIPSEhuman brain MRSIlipidsouter volume suppression

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Area of Science:

  • Medical Imaging
  • Neuroimaging
  • Spectroscopy

Background:

  • Proton magnetic resonance spectroscopic imaging (MRSI) at high fields faces challenges with extracranial lipid contamination.
  • This contamination hinders robust and reliable MRSI utilization in the human brain.

Purpose of the Study:

  • To develop and present novel lipid suppression sequences for proton MRSI in the human brain.
  • The sequences utilize elliptical localization with pulsed second-order fields (ECLIPSE) to overcome technical difficulties.

Main Methods:

  • Two lipid suppression methods were implemented with the ECLIPSE gradient insert: outer volume suppression (OVS) and inversion recovery (IR).
  • The ECLIPSE-OVS sequence was compared against a standard 8-slice OVS method.
  • The ECLIPSE-IR sequence was compared against a global IR method.

Main Results:

  • ECLIPSE-OVS achieved a 116-fold mean lipid suppression, significantly outperforming the 8-slice OVS method (15-fold).
  • ECLIPSE-OVS required only 30% of the radiofrequency (RF) power compared to the standard method.
  • The ECLIPSE-IR sequence provided 155-fold skull lipid suppression, compared to 16-fold for the standard IR method.

Conclusions:

  • ECLIPSE-based OVS and IVS offer robust and effective lipid suppression.
  • These methods operate at reduced RF power and exhibit high immunity to B1 and T1 variations.
  • This advancement enhances the reliability of proton MRSI in the human brain.