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Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
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Regulation and Effects of FGF23 in Chronic Kidney Disease

John Musgrove1, Myles Wolf1,2

  • 1Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA;

Annual Review of Physiology
|November 20, 2019
PubMed

Insights

Fibroblast growth factor 23 (FGF23) plays a key role in chronic kidney disease (CKD) complications. Research into FGF23 in CKD is driving new therapies for mineral metabolism disorders.

Area of Science:

  • Nephrology
  • Endocrinology
  • Cardiovascular Disease

Background:

  • Chronic kidney disease (CKD) is a global health issue with severe complications, including cardiovascular disease, infection, anemia, and bone disease.
  • Disordered mineral metabolism, particularly calcium and phosphate homeostasis, is a significant risk factor in CKD progression and morbidity.
  • Fibroblast growth factor 23 (FGF23) has emerged as a critical factor in understanding and managing rare genetic disorders and CKD-related mineral metabolism issues.

Purpose of the Study:

  • To explore the evolving understanding of fibroblast growth factor 23 (FGF23) in the context of chronic kidney disease (CKD).
  • To highlight the impact of FGF23 discovery on the pathophysiology and complications of disordered mineral metabolism in CKD.
  • To discuss the emerging research questions and innovations in FGF23-targeted therapies for CKD.

Main Methods:

  • Review of recent laboratory, patient-oriented, and epidemiological research on FGF23 in CKD.
  • Analysis of the role of FGF23 in mineral metabolism and its downstream effects in CKD.
  • Examination of ongoing clinical trials for FGF23-targeting therapies in CKD.

Main Results:

  • FGF23 has revolutionized the understanding of rare FGF23-related disorders and significantly impacted CKD pathophysiology.
  • Research on FGF23 in CKD is rapidly advancing, revealing new insights into its regulation and effects.
  • The study of FGF23 is stimulating the development of novel therapeutic strategies for CKD complications.

Conclusions:

  • FGF23 is central to understanding mineral metabolism disorders in CKD.
  • Continued research into FGF23 is crucial for developing innovative treatments for CKD patients.
  • Targeting FGF23 holds promise for mitigating major CKD morbidities and improving patient outcomes.

Keywords:
Klothocardiovascular diseasechronic kidney diseasefibroblast growth factor 23inflammationiron

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