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Targeted therapy clinical trials in ovarian cancer: improved outcomes by gene mutation screening

Quan Guo1, Qing Yang1, Jun Li1

  • 1Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, China.

Anti-Cancer Drugs
|November 20, 2019
PubMed

Insights

Epithelial ovarian cancer treatments need improvement. Gene profiling in clinical trials helps select patients for targeted therapies, potentially improving survival rates and reducing side effects.

Area of Science:

  • Oncology
  • Genetics
  • Clinical Trials

Background:

  • Epithelial ovarian cancer is a leading cause of gynecologic cancer death.
  • Current chemotherapy options have limitations.
  • Targeted therapies, like PARP and angiogenesis inhibitors, show promise.

Purpose of the Study:

  • To review phase II and III ovarian cancer clinical trials focusing on gene profiling.
  • To discuss the impact of gene mutation screening on trial success and patient selection.
  • To analyze lessons from successful and failed trials and implications for ongoing studies.

Main Methods:

  • Searched PubMed and ClinicalTrials.gov databases.
  • Focused on phase III and selected phase II ovarian cancer clinical trials.
  • Included studies investigating gene profiling and targeted therapies.

Main Results:

  • Gene mutation screening is crucial for improving ovarian cancer trial success rates.
  • Basket trials are increasingly using genetic alterations for patient selection.
  • Targeted therapies impact cell signaling pathways relevant to ovarian cancer.

Conclusions:

  • Gene profiling enhances patient selection for targeted ovarian cancer therapies.
  • Understanding genetic alterations is key to improving treatment outcomes.
  • Lessons from past and ongoing trials inform future therapeutic strategies.

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