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Multilayered Activatable Nanoprobe for Ultra-Bright Tumor Imaging
Seung Koo Lee1, Myung Shin Han1, Weiqi Zhang1
1Molecular Imaging Innovations Institute, Department of Radiology, Weill Cornell Medicine, 413 East 69th Street, Box 290, New York, NY, 10021, USA.
Macromolecular Bioscience
|November 20, 2019
Summary
Researchers developed a multilayered activatable nanoprobe (MAN) for enhanced cancer imaging. This novel probe significantly improves tumor signal and contrast, offering a promising platform for sensitive tumor detection.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cancer Research
Background:
- Developing tumor-targeted probes with high signal and contrast for cancer imaging remains a significant challenge.
- Existing probes often face limitations in signal amplification and specificity.
Purpose of the Study:
- To create a novel multilayered activatable nanoprobe (MAN) for enhanced tumor imaging.
- To overcome the limitations of current probes by maximizing signal and contrast.
Main Methods:
- Utilized a layer-by-layer fabrication technique to assemble polyelectrolytes onto nanoparticles.
- Incorporated a high quantity of quenched fluorochromes for signal amplification.
- Evaluated probe performance in cell studies and in vivo mouse models.
Main Results:
- MAN demonstrated significant fluorescence enhancement and signal amplification with negligible cytotoxicity in cell studies.
- In vivo studies showed rapid tumor accumulation and protease-activated fluorescence.
- Achieved over 700% increase in tumor-to-normal-tissue contrast.
Conclusions:
- The multilayered fabrication provides a versatile and powerful platform for designing sensitive tumor imaging probes.
- MAN technology offers a significant advancement in cancer imaging sensitivity and contrast.
- This approach holds potential for improved early cancer detection and diagnosis.
