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Cell Biology: Hacking Alpha Satellites out of the HAC
Alexander B Willis1, Daniel R Foltz2
1Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Current Biology : CB
|November 20, 2019
Abstract:
Human artificial chromosomes (HACs) are a potentially powerful technique for genomic engineering, but their use is limited by the repetitive centromeric alpha-satellite DNA needed to form a centromere. A new study presents a method to induce HAC centromere formation on non-repetitive templates through sequence-directed CENP-A nucleosome seeding.
