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A review for the peripheral nerve interface designer.

Christopher E Larson1, Ellis Meng2

  • 1Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, 90089, USA.

Journal of Neuroscience Methods
|November 20, 2019
PubMed
Summary
This summary is machine-generated.

This review details best practices for designing peripheral nerve interfaces (PNIs). It addresses challenges in neural target resolution and stability for advanced therapeutic applications.

Keywords:
Bioelectronic medicineBrain machine interfaceFunctional electrical stimulationNeural prosthesisPeripheral nerve interfaceVagus nerve stimulation

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Medical Devices

Background:

  • Peripheral nerves offer accessible sites for therapeutic interventions.
  • Electrode-based electrophysiological interfaces for peripheral nerves have a long history of development and clinical use.
  • Existing peripheral nerve interfaces (PNIs) often lack the required neural target resolution and long-term stability for advanced applications.

Purpose of the Study:

  • To provide PNI designers with practical considerations and best practices for developing next-generation devices.
  • To consolidate lessons learned from early PNI development and recent innovations.
  • To guide the creation of PNIs that meet demanding application requirements.

Main Methods:

  • Review of fundamental and practical principles guiding PNI design.
  • Critical analysis of existing PNI designs and strategies.
  • Survey of in vitro and in vivo characterization methods for PNIs.

Main Results:

  • Identification of key challenges in achieving high neural target resolution and stability with current PNIs.
  • Compilation of best practices and lessons learned from historical and recent PNI development.
  • Overview of established and emerging methods for evaluating PNI performance.

Conclusions:

  • Improved PNI design requires addressing limitations in neural resolution and stability.
  • A comprehensive understanding of design principles and characterization methods is crucial for advancing PNI technology.
  • This review serves as a resource for engineers and researchers aiming to develop more effective peripheral nerve interfaces.