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Mucosal impact of alcoholic povidone-iodine indicated in preoperative disinfection

F Bruyère1, P Laine1, G Saint-Jalmes1

  • 1Service d'Urologie, CHRU Tours, France; Université François Rabelais de Tours, PRES Centre Val de Loire, Tours, France.

The Journal of Hospital Infection
|November 20, 2019
PubMed
Abstract

Insights

Alcoholic povidone-iodine (API) is safe for use on genital mucous membranes. This study found no significant impact on the glans mucosa, supporting its potential use in urology procedures.

Area of Science:

  • Urology
  • Dermatology
  • Infectious Disease Prevention

Background:

  • Alcoholic povidone-iodine (API) is a recognized antiseptic for skin disinfection.
  • Evidence for API's safety on mucous membranes, particularly genital mucosa, is lacking.
  • Postoperative infections risk reduction necessitates evaluating antiseptic efficacy and safety on diverse anatomical sites.

Purpose of the Study:

  • To assess the safety and tolerance of alcoholic povidone-iodine (API) application on the glans penis mucosa.
  • To provide the first analysis of API's impact on genital mucous membranes in a clinical setting.

Main Methods:

  • A tolerance study involving Caucasian men undergoing endoscopic transurethral urological surgery.
  • Colorimetric measurements (L*a*b*) of the glans mucosa were taken preoperatively and postoperatively.
  • Quantification of color change using the ΔE formula to determine mucosal impact.

Main Results:

  • Ninety-six patients were included in the study.
  • No statistically significant differences were observed in L*, a*, or b* parameters post-API application (P > 0.05).
  • The overall color change (ΔE) was not significant, indicating no adverse mucosal effects.

Conclusions:

  • Alcoholic povidone-iodine (API) demonstrated no significant impact on the glans penis mucosa under the study conditions.
  • Findings suggest that API can be safely used for disinfection of genital mucous membranes in urological procedures.
  • This study provides initial evidence supporting the safe application of API on genital mucosa.
Keywords:
AlcoholDisinfectionPostoperativePovidoneUrology

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