Effects of rice straw structure on chaetoglobosin A production by Chaetomium globosum CGMCC 6882

As the most abundant macromolecules in nature, lignocelluloses are served as a promising and renewable source for sustainable production of high value chemical compounds. In present work, extrusion pretreatment with 23% (w/w) distilled water, 2% (w/w) glycerol and 1 g/L NaHCO₃ as moisture agent, not only reduced the particle size, crystallinity and component contents (cellulose, hemicelluloses and lignin) of rice straw, but also effectively enhanced chaetoglobosin A yield and degradation rate of rice straw by C. globosum CGMCC 6882. Meanwhile, mycelial biomass of C. globosum CGMCC 6882 increased from 2.9 g/L to 7.0 g/L, mycelia growth time reduced by 2 days and chaetoglobosin A titer increased from 108.4 mg/L to 270.2 mg/L, representing an increase of 149.3%. Furthermore, degradation rate of rice straw by C. globosum CGMCC 6882 increased from 28.93% to 65.38%. This work provides a good guidance for production of chaetoglobosin A from lignocelluloses.