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Topoisomerase inhibitors: Pharmacology and emerging nanoscale delivery systems

Ali Dehshahri1, Milad Ashrafizadeh2, Elham Ghasemipour Afshar3

  • 1Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran.

Pharmacological Research
|November 20, 2019
PubMed

Insights

Nano-delivery systems enhance topoisomerase inhibitors for cancer therapy by improving drug properties. This approach aims to overcome limitations of existing treatments and develop novel therapeutic agents.

Area of Science:

  • Biochemistry and Molecular Biology
  • Pharmacology and Pharmaceutical Sciences
  • Nanotechnology in Medicine

Background:

  • Topoisomerase enzymes play critical roles in DNA replication and transcription.
  • Topoisomerase inhibitors are established cancer therapeutics but face challenges like toxicity and poor solubility.
  • Existing inhibitors require improved pharmacokinetic profiles for broader clinical application.

Purpose of the Study:

  • To review various nano-delivery systems for enhancing topoisomerase inhibitors.
  • To explore how nanotechnology can overcome the limitations of current topoisomerase-targeted cancer drugs.
  • To highlight the potential of nano-delivery systems in developing novel therapeutic agents.

Main Methods:

  • Literature review of nano-delivery vehicles used with topoisomerase inhibitors.
  • Analysis of studies demonstrating improved physicochemical and pharmacokinetic properties.
  • Examination of research on targeted delivery of topoisomerase inhibitors via nanocarriers.

Main Results:

  • Nano-delivery systems can significantly modify the properties of topoisomerase inhibitors.
  • Nanocarriers facilitate targeted delivery, potentially reducing systemic toxicity.
  • Repurposing existing drugs through nanoformulation offers improved therapeutic potential.

Conclusions:

  • Nano-delivery systems offer a promising strategy to enhance the efficacy and safety of topoisomerase inhibitors.
  • Nanotechnology enables the development of novel formulations with improved drug delivery characteristics.
  • This approach holds potential for advancing cancer therapy by optimizing existing drug candidates.
Keywords:
CancerChemotherapyDrug delivery systemsNanocarriersNanoparticlesTopoisomerase inhibitors

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