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Epinephrine Use in Endoscopic Ear Surgery: Quantitative Safety Assessment
Matteo Alicandri-Ciufelli1, Giulia Molinari2, Sven Beckmann3
1Department of Otorhinolaryngology - Head and Neck Surgery, AOU Policlinico di Modena, University of Modena and Reggio Emilia, Modena, Italy.
Topical and injected diluted epinephrine is safe for managing bleeding in endoscopic ear surgery (EES). This study found no major adverse cardiovascular events, supporting its use in EES procedures.
Area of Science:
- Otolaryngology
- Surgical Hemostasis
- Endoscopic Ear Surgery
Background:
- Bleeding management in endoscopic ear surgery (EES) often relies on epinephrine.
- The safety and efficacy of epinephrine in EES have not been previously evaluated.
Purpose of the Study:
- To assess the safety of topical and/or local infiltration of diluted epinephrine during EES.
- To evaluate intraoperative and postoperative safety profiles of epinephrine use in EES.
Main Methods:
- Retrospective analysis of 90 EES cases.
- Review of patient charts and surgical video recordings.
Main Results:
- Epinephrine was used in all cases via injection (1:200,000) and topical application (1:1,000).
- No major cardiovascular adverse events were observed; two intraoperative hypertensive events occurred.
- One case of sensorineural hearing loss and no facial palsy were recorded.
Conclusions:
- Combined local injection and topical epinephrine is a safe and effective method for bleeding control in EES.
- Epinephrine use within reported dilutions and quantities is supported for EES.
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