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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
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OCT angiography in optic disc drusen: comparison with structural and functional parameters.

Hendrik Engelke1, Mehdi Shajari2, Julian Riedel3,2

  • 1Department of Ophthalmology, Ludwig-Maximilians-Universitat Munchen, Munich, Germany tohendrik@gmail.com.

The British Journal of Ophthalmology
|November 21, 2019
PubMed
Summary

Optic disc drusen (ODD) are linked to reduced optic disc vessel density (VD), impacting retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) thickness. These microvascular changes correlate with visual field defects.

Keywords:
AngiovueOptovueganglion cell complexoptic disc drusenoptic nerve head drusenoptical coherence tomographyoptical coherence tomography angiographyretinal nerve fiber layerstructure-functionvisual field defect

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Medical Imaging

Background:

  • Optic disc drusen (ODD) can lead to retinal nerve fibre layer (RNFL) defects and progressive visual field (VF) loss.
  • Microvascular changes are implicated as a potential cause of these visual impairments.

Purpose of the Study:

  • To measure optic disc vessel density (VD) in patients with ODD using optical coherence tomography angiography.
  • To compare VD in ODD patients with a healthy control group.
  • To assess the correlation of VD with functional (VF) and structural parameters (RNFL, minimum rim width (MRW), ganglion cell complex (GCC)).

Main Methods:

  • Vessel density (VD) analysis was performed on 25 ODD patients and 25 healthy controls using AngioVue OCT angiography.
  • RNFL, GCC, MRW, and VF data were collected using Spectralis HRA & OCT and standard automated perimetry.
  • Statistical analysis included t-tests, Mann-Whitney U tests, and linear regression with Bravais-Pearson correlation.

Main Results:

  • Significantly reduced peripapillary VD was observed in the ODD group compared to controls.
  • Peripapillary RNFL thickness and GCC showed significant reductions in ODD patients.
  • Strong positive correlations were found between VD and RNFL thickness, and between VD and GCC.
  • A significant negative correlation was identified between VD and pattern standard deviation (PSD) of VF.

Conclusions:

  • This study demonstrates significant peripapillary microvascular changes in patients with ODD.
  • These microvascular alterations correlate with reductions in RNFL and GCC.
  • A negative correlation exists between vessel density and visual field pattern standard deviation, suggesting functional impact.