Related Experiment Video
Updated: Jan 3, 2026
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
720
Carcinoid Heart Disease: a Comprehensive Review
Saamir A Hassan1, Nicolas L Palaskas2, Ali M Agha2
1Department of Cardiology, Division of Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. sahassan1@mdanderson.org.
Current Cardiology Reports
|November 21, 2019
Summary
Carcinoid heart disease, a rare condition linked to neuroendocrine tumors, requires early diagnosis using echocardiography and NT-proBNP screening. Surgery remains the primary treatment for this serious cardiac complication.
Area of Science:
- Cardiology
- Oncology
- Medical Imaging
Background:
- Carcinoid heart disease (CHD) is a rare but serious complication in patients with neuroendocrine tumors and carcinoid syndrome.
- Serotonin is implicated as a key factor in the pathogenesis of CHD.
Purpose of the Study:
- To review current concepts in the diagnosis and management of carcinoid heart disease.
- To highlight recent advances in the evaluation and treatment of CHD.
Main Methods:
- Literature review focusing on expert consensus guidelines and recent findings.
- Discussion of diagnostic tools including echocardiography and cardiac biomarkers (e.g., NT-proBNP).
- Exploration of imaging modalities and the role of medical and surgical therapies.
Main Results:
- Expert guidelines emphasize echocardiography and NT-proBNP for CHD evaluation.
- Advances in medical therapy and surgical outcomes have improved treatment.
- Early screening and diagnosis are crucial for effective management.
Conclusions:
- Carcinoid heart disease necessitates a multidisciplinary approach involving cardiology and oncology.
- Prompt diagnosis via biomarkers and imaging, followed by surgical intervention, is key to improving patient outcomes.
Related Concept Videos
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
329
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
329
01:29Heart Failure II: Pathophysiology
633
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
633
01:26Coronary Artery Disease II: Pathophysiology
322
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
322
01:21Barrett Esophagus-II: Clinical Manifestations and Management
701
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
701
01:30Coronary Artery Disease I: Introduction
827
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
827
01:30Heart Failure IV: Classification and Diagnostic Evaluation
264
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
264