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Updated: Jan 3, 2026
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SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
Published on: June 28, 2019
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Targeting senescent cells in translational medicine
Marta Paez-Ribes1, Estela González-Gualda1, Gary J Doherty2
1Department of Oncology, CRUK Cambridge Centre Early Detection Programme, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, UK.
EMBO Molecular Medicine
|November 21, 2019
Summary
Cellular senescence, a hallmark of aging, involves cell cycle arrest and accumulation of senescent cells, contributing to tissue dysfunction and age-related diseases. Targeting these cells offers therapeutic potential for age-related disorders.
Area of Science:
- Gerontology and Cellular Biology
- Biomedical Research
Background:
- Organismal aging involves progressive functional decline and reduced tissue regeneration.
- Cellular senescence, a stable cell cycle arrest, is a key hallmark of aging.
- Senescent cells accumulate with age, impairing tissue function and contributing to pathologies.
Purpose of the Study:
- To review senolytics, drug delivery tools, and probes for targeting and tracing senescent cells.
- To discuss the clinical research landscape of cellular senescence.
- To explore the potential of targeting cellular senescence in aging and disease.
Main Methods:
- Literature review of senolytics and senescent cell tracing probes.
- Analysis of preclinical therapeutic strategies.
- Examination of the clinical research landscape in senescence.
Main Results:
- Senolytics and drug delivery tools are being developed for preclinical strategies.
- Probes for in vivo identification of senescent cells show diagnostic potential.
- Targeting senescent cells is a promising therapeutic approach for age-related disorders.
Conclusions:
- Cellular senescence is a significant factor in aging and age-related diseases.
- Targeted elimination of senescent cells can ameliorate tissue damage and promote regeneration.
- Identifying and targeting cellular senescence holds promise for treating pathological and aging processes.
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