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Polyamines: The possible missing link between mental disorders and epilepsy (Review).

Giulia Baroli1, Jonathan Reinoso Sanchez1, Enzo Agostinelli2

  • 1Department of Science, University of Rome 'Roma Tre', I‑00146 Rome, Italy.

International Journal of Molecular Medicine
|November 21, 2019
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Polyamines are vital for cell function. Their dysregulation is linked to tumors, mental disorders, and epilepsy, suggesting polyamine metabolism modulation as a therapeutic target.

Keywords:
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Area of Science:

  • Biochemistry
  • Neuroscience
  • Oncology

Background:

  • Polyamines are essential for eukaryotic cell processes.
  • Their metabolism is tightly regulated but dysregulation is linked to cancer and neurological diseases.
  • Altered polyamine levels are observed in brain disorders like epilepsy and mental illness.

Purpose of the Study:

  • To review the role of polyamines in mental disorders and epilepsy.
  • To explore the potential link between these two pathologies.
  • To propose polyamines as a common factor in central nervous system disorders.

Main Methods:

  • Literature review of polyamine roles in eukaryotic processes.
  • Analysis of polyamine involvement in cancer and brain diseases.
  • Exploration of neurochemical circuit associations.

Main Results:

  • Polyamine dysregulation is a hallmark of various tumors.
  • Altered polyamine levels are implicated in mental disorders and epilepsy.
  • Polyamines modulate ion channels and glutamate receptors, impacting neuronal function.

Conclusions:

  • Polyamines may act as protective molecules in the brain.
  • The high comorbidity of mental disorders and epilepsy suggests shared polyamine-related pathways.
  • Modulating polyamine metabolism offers a potential therapeutic strategy for these conditions.