Related Experiment Video
Updated: Jan 3, 2026

Assessing Activity-based Anorexia in Mice
Published on: May 14, 2018
5-HT2AR and BDNF gene variants in eating disorders susceptibility
M Rachele Ceccarini1, Anna Tasegian1, Marica Franzago2,3
1Department of Pharmaceutical Science, University of Perugia, Perugia, Italy.
Abstract:
Evidence from family and twin studies points to a genetic contribution to the etiology of eating disorders (EDs), confirmed by the association of several single nucleotide polymorphisms (SNPs) with this group of disorders. Previous reports have suggested that the serotonin receptor (5-HT2AR) and brain-derived neurotrophic factor (BDNF) genes could be both involved in EDs susceptibility. In order to provide further evidence about such association, we focused our attention on two SNPs located in these genes carrying out a genetic association study on a large Italian cohort composed of 556 ED patients and 355 controls (CTRs). Obtained results confirm the presence of an association between 5-HT2AR and BDNF genes and the susceptibility to EDs.
Related Concept Videos
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Bulimia Nervosa
Anorexia Nervosa
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Binge Eating Disorders
Regulation of Food Intake
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

