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Updated: Jan 3, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
Published on: June 27, 2020
TFmiR2: constructing and analyzing disease-, tissue- and process-specific transcription factor and microRNA
Maryam Nazarieh1,2, Mohamed Hamed3, Christian Spaniol4
1Center for Bioinformatics, Saarland University, Saarbrucken 66041, Germany.
Summary:
TFmiR2 is a freely available web server for constructing and analyzing integrated transcription factor (TF) and microRNA (miRNA) co-regulatory networks for human and mouse. TFmiR2 generates tissue- and biological process-specific networks for the set of deregulated genes and miRNAs provided by the user. Furthermore, the service can now identify key driver genes and miRNAs in the constructed networks by utilizing the graph theoretical concept of a minimum connected dominating set. These putative key players as well as the newly implemented four-node TF-miRNA motifs yield novel insights that may assist in developing new therapeutic approaches.
Availability And Implementation:
The TFmiR2 web server is available at http://service.bioinformatik.uni-saarland.de/tfmir2.
Supplementary Information:
Supplementary data are available at Bioinformatics online.
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