Divergent Reactivity in CuII-Catalyzed Oxidative Coupling between Indole/Tryptamine Derivatives and β-Arylacrylic
Wei Cao1, Jinbao Fan1, Linyang Yan1
1Xiangya School of Pharmaceutical Science , Central South University , Changsha 410013 , Hunan , China.
Abstract:
Condition-controlled divergent oxidative coupling reactions between indole/tryptamine derivatives and β-arylacrylic acids with the catalysis of copper(II) have been developed. Specifically, a formal Michael addition/dehydration sequence between indoles and β-arylacrylic acids occurred in the presence of catalytic CuBr2 in CH3CN under air, thus affording highly functionalized 2,3-dihydro-1H-pyrrolo[1,2-a]indoles. In contrast, upon changing the oxidant to BuOOH and the solvent to DCM, the reaction course switched to the unprecedented oxidative coupling/cyclization cascade to give the tetracyclic pyrrolo[2,3-b]indolines selectively.
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