Asymmetric Total Synthesis Enables Discovery of Antibacterial Activity of Siladenoserinols A and H
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Updated: Jan 3, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
Published on: October 17, 2019
Miguel Adrián Márquez-Cadena1, Jingyun Ren1, Wenkang Ye2
1Department of Chemistry , The Hong Kong University of Science and Technology , Hong Kong , China.
Abstract:
Siladenoserinols A and H were found to show moderate inhibitory activity toward p53-Hdm2 interactions. Our total synthesis allowed us to further examine their bioactivities, which revealed that (i) siladenoserinols A and H were not cytotoxic against cancer cell lines and (ii) siladenoserinol A and its desulfamate analogue exhibited significant antibacterial activity against Gram-positive bacteria including MRSA. Our studies demonstrate that siladenoserinols are a promising new class of bactericidal Gram-positive antibiotics without hemolytic activity.
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