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Functional connectivity studies in migraine: what have we learned?
Kirill Skorobogatykh1, Willem Sebastiaan van Hoogstraten2, Diana Degan3
1University Headache Clinic, Moscow, Russia.
The Journal of Headache and Pain
|November 22, 2019
Summary
Resting-state functional connectivity MRI studies show poor reproducibility and no specific pattern for migraine diagnosis. Standardized guidelines are needed for future migraine research.
Area of Science:
- Neuroimaging
- Neurology
- Medical Imaging
Background:
- Resting-state functional connectivity (FC) MRI is utilized to investigate migraine pathophysiology.
- FC MRI aims to identify potential imaging biomarkers for migraine diagnosis.
Purpose of the Study:
- To review findings from resting-state FC MRI studies in migraine.
- To assess the current understanding of migraine pathophysiology and potential biomarkers derived from FC MRI.
Main Methods:
- A literature search was conducted on PubMed for original articles on resting-state FC MRI in migraine.
- Studies compared migraine patients with healthy controls or examined patients during and outside of attacks.
Main Results:
- 28 studies were included, analyzing alterations in over 20 FC networks.
- A poor level of reproducibility and no migraine-specific pattern were observed across studies.
- Significant alterations were reported in networks including the default mode, executive control, and salience networks.
Conclusions:
- Extracting knowledge on migraine pathophysiology or identifying a reliable biomarker from current FC MRI studies is challenging.
- There is a need for standardized guidelines for resting-state FC MRI in migraine research.
- Guidelines should promote homogenous terminology, data sharing, and a priori hypotheses.
