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Worldwide burden of LDL cholesterol: Implications in cardiovascular disease

Camilla Mattiuzzi1, Fabian Sanchis-Gomar2, Giuseppe Lippi3

  • 1Service of Clinical Governance, Provincial Agency for Social and Sanitary Services, Trento, Italy.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|November 22, 2019
PubMed

Insights

High low-density lipoprotein cholesterol (LDL-C) significantly impacts global health, causing millions of deaths and disability-adjusted life years (DALYs). Urgent healthcare policies are needed to address this growing cardiovascular disease risk factor.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Elevated low-density lipoprotein cholesterol (LDL-C) is a primary risk factor for cardiovascular disease (CVD).
  • LDL-C is integral to global CVD risk prediction and prevention guidelines.
  • This study provides an overview of the global healthcare burden attributed to LDL-C.

Purpose of the Study:

  • To assess the worldwide adverse healthcare impact of elevated low-density lipoprotein cholesterol (LDL-C).

Main Methods:

  • Epidemiological data on LDL-C levels exceeding 1.3 mmol/L were sourced from the Global Health Data Exchange (GHDx) registry.
  • Analysis focused on disability-adjusted life years (DALYs) and mortality attributable to high LDL-C.

Main Results:

  • The current global burden is 94.92 million DALYs, with an exponential increase over the last 25 years.
  • 4.32 million deaths are linked to LDL-C levels above 1.3 mmol/L.
  • DALYs and deaths from LDL-C have risen globally, except in high socio-demographic index countries.

Conclusions:

  • Effective, large-scale healthcare policies are essential to combat the epidemic of LDL-C-related health loss.
  • Addressing high LDL-C is critical for global cardiovascular health and reducing disease burden.
Abstract

Keywords:
AtherosclerosisCardiovascular diseaseCholesterolLow-density lipoproteins

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