Related Experiment Video
Updated: Dec 29, 2025
04:37
Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
Published on: April 25, 2025
1.3K
Rivaroxaban-Induced Acute Interstitial Nephritis: A Case Report
Fahad Zafar1, Arshad Muhammad Iqbal1, Ateeq Mubarik1
1Department of Internal Medicine, Oak Hill Hospital, Brooksville, FL, USA.
The American Journal of Case Reports
|November 22, 2019
Summary
Direct oral anticoagulants like rivaroxaban are common, but can cause acute interstitial nephritis. This rare condition requires removing the drug and may need corticosteroid treatment.
Area of Science:
- Nephrology
- Pharmacology
Background:
- Direct oral anticoagulants (DOACs) are increasingly used, often replacing warfarin for conditions like atrial fibrillation.
- Rivaroxaban is a widely prescribed DOAC for anticoagulation and preventing thromboembolic events.
Observation:
- A 70-year-old male developed acute interstitial nephritis after initiating rivaroxaban therapy.
- The patient responded well to treatment including corticosteroids.
Findings:
- Acute interstitial nephritis is a rare adverse effect associated with DOACs.
- Renal biopsy was not performed due to the patient's high CHADS2VASc score necessitating continued anticoagulation.
Implications:
- Rivaroxaban dose adjustments are crucial for patients with renal impairment.
- Discontinuation of the offending agent and supportive care are key in managing drug-induced acute interstitial nephritis.
Related Concept Videos
01:22Acute Kidney Injury VI: Nursing Management
304
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
304
01:20Acute Kidney Injury V: Interprofessional Care
228
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
228
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
217
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
217
01:29Acute Kidney Injury III: Clinical Manifestations
694
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
694
01:29Acute Kidney Injury II: Pathophysiology
762
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
762
01:22Acute Kidney Injury I: Introduction
449
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
449