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Pathways to cellular supremacy in biocomputing.

Lewis Grozinger1, Martyn Amos2, Thomas E Gorochowski3,4

  • 1School of Computing, Newcastle University, Newcastle Upon Tyne, NE4 5TG, UK.

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Summary
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Synthetic biology, or biocomputing, can achieve "cellular supremacy" by moving beyond the genetic circuit metaphor. This approach unlocks superior computational performance in living cells for novel applications.

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Area of Science:

  • Synthetic biology
  • Biocomputing
  • Cellular computation

Background:

  • Current cellular computing relies on the "genetic circuit" metaphor, mimicking silicon-based computers.
  • This metaphor limits the scope of computations that can be engineered within cells.
  • It fails to leverage the full potential of natural biological systems.

Purpose of the Study:

  • To propose the concept of "cellular supremacy" for biocomputing.
  • To identify areas where biological computation may outperform traditional computers.
  • To explore potential pathways and applications for achieving cellular supremacy.

Main Methods:

  • Conceptual analysis of current synthetic biology approaches.
  • Development of the "cellular supremacy" framework.
  • Identification of potential application domains for advanced biocomputing.

Main Results:

  • The genetic circuit metaphor is a limiting factor in cellular computing.
  • "Cellular supremacy" offers a new paradigm for biocomputing.
  • Specific domains where biocomputing could surpass traditional computing were identified.

Conclusions:

  • Rethinking the approach to cellular computing beyond the genetic circuit metaphor is crucial.
  • The concept of "cellular supremacy" provides a framework for advancing biocomputing.
  • Harnessing the unique capabilities of living systems can lead to powerful new computational tools.