Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depression: Overview01:18

Depression: Overview

721
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
721
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

526
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
526
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

392
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
392
Long-term Depression01:05

Long-term Depression

32.9K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
32.9K
Long-term Depression01:03

Long-term Depression

3.0K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.0K
Stress and Mental Health01:30

Stress and Mental Health

442
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
442

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness and safety of repeat dose subcutaneous ketamine for treatment-resistant depression, and the impact of prior ketamine treatment: open label extension of the KADS study.

The British journal of psychiatry : the journal of mental science·2026
Same author

Evaluating the abuse liability of ketamine in the treatment of mood disorders: A systematic review.

Journal of psychopharmacology (Oxford, England)·2026
Same author

Towards an Integrated Staging Model for Bipolar Disorders: An International Society for Bipolar Disorders (ISBD) Staging Task Force Consensus Report.

Bipolar disorders·2026
Same author

The Serotonin 2B (5-HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression.

Clinical pharmacology and therapeutics·2026
Same author

Geographic Variation in Loneliness and Social Isolation in Australia: Socio-Demographic and Healthcare Utilisation Determinants.

Healthcare (Basel, Switzerland)·2026
Same author

Guidelines for the prevention of psychosis from the World Federation of Societies of Biological Psychiatry (WFSBP) and EPI Canada.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2026
Same journal

Diagnostic complexities of autism and psychosis: A commentary on the ANZJP GRADE guidelines for the management of schizophrenia.

The Australian and New Zealand journal of psychiatry·2026
Same journal

Cardiometabolic screening, elevated results and clinical follow-up actions in Ma-ori and non-Ma-ori with psychosis in Canterbury, Aotearoa New Zealand.

The Australian and New Zealand journal of psychiatry·2026
Same journal

Author reply to Letter to the Editor regarding 'Middle childhood profiles of social-emotional competencies and difficulties differentiate risk of health service presentations with adolescent mental disorders'.

The Australian and New Zealand journal of psychiatry·2026
Same journal

Letter to the Editor regarding 'Middle childhood profiles of social-emotional competencies and difficulties differentiate risk of health service presentations with adolescent mental disorders'.

The Australian and New Zealand journal of psychiatry·2026
Same journal

Diagnostic complexity and comorbidity: Implications for identification, outcomes, health care and involuntary treatment.

The Australian and New Zealand journal of psychiatry·2026
Same journal

Defining and measuring psychosocial disability in Australia: Assessment of national surveys and administrative datasets.

The Australian and New Zealand journal of psychiatry·2026
See all related articles

Related Experiment Video

Updated: Jan 3, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

21.9K

Depression in the medically ill.

Joshua D Rosenblat1,2, Paul Kurdyak2,3,4, Fiammetta Cosci5,6

  • 1Mood Disorder Psychopharmacology Unit, University Health Network, Toronto, ON, Canada.

The Australian and New Zealand Journal of Psychiatry
|November 22, 2019
PubMed
Summary
This summary is machine-generated.

Depression is common in medically ill patients, impacting physical health and treatment adherence. Early recognition and stepped care, including psychological and pharmacological interventions, are crucial for managing depression in this population.

Keywords:
Major depressive disorderadjustment disorderantidepressantcancerorganic illnesspsychosomaticspsychotherapyscreening

More Related Videos

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.2K
An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.3K

Related Experiment Videos

Last Updated: Jan 3, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

21.9K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.2K
An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.3K

Area of Science:

  • Medical Psychology
  • Psychiatry
  • Clinical Medicine

Background:

  • Depressive disorders are more prevalent in medically ill individuals than the general population.
  • Depression exacerbates physical symptoms, increases healthcare use, and hinders treatment adherence.
  • Effective assessment and management strategies for depression in medically ill patients are critical.

Purpose of the Study:

  • To critically review the assessment and management of depression in medically ill patients.
  • To synthesize current knowledge on recognizing and treating depression in diverse medical settings.
  • To provide evidence-based recommendations for clinical practice.

Main Methods:

  • A qualitative synthesis of relevant articles on depression in the medically ill.
  • Expert review and synthesis of notable studies due to the topic's breadth.
  • Non-systematic literature review approach.

Main Results:

  • Depression is often under-recognized in medical settings, with differential diagnoses including delirium and substance-induced disorders.
  • A stepped care approach is recommended, starting with psychoeducation and psychosocial interventions for mild to moderate depression.
  • Antidepressants and higher-intensity psychotherapy are options for moderate to severe symptoms or treatment-resistant cases, with careful consideration of side effects and drug interactions.

Conclusions:

  • A bidirectional relationship exists between depression and medical illness.
  • Screening for depression in medically ill patients is warranted.
  • A stepped care model integrating pharmacological and non-pharmacological interventions is recommended.