Related Experiment Video
Updated: Jan 3, 2026

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
Published on: October 11, 2019
OSacc: Gene Expression-Based Survival Analysis Web Tool For Adrenocortical Carcinoma
Longxiang Xie1, Qiang Wang1, Fangmei Nan1
1Bioinformatics Department of Predictive Medicine, Institute of Biomedical Informatics, Cell Signal Transduction Laboratory, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Software, School of Basic Medical Sciences, Henan University, Kaifeng 475004, People's Republic of China.
A new web tool, OSacc, enables researchers to analyze gene expression and clinical data for Adrenocortical Carcinoma (ACC) patients. This tool facilitates the evaluation of prognostic biomarkers using survival analysis, aiding translational cancer research.
Area of Science:
- Bioinformatics
- Translational Cancer Research
- Genomics
Background:
- Gene expression profiling and clinical data are crucial for identifying prognostic biomarkers in cancer research.
- A need exists for accessible online tools to analyze these complex datasets.
- Adrenocortical Carcinoma (ACC) research can benefit from integrated analysis of transcriptomic and clinical data.
Purpose of the Study:
- To develop an interactive web tool, OSacc, for user-friendly survival analysis of ACC patient data.
- To enable the evaluation of prognostic biomarker value using gene expression and clinical follow-up information.
- To provide a platform for researchers and clinicians to analyze Adrenocortical Carcinoma data.
Main Methods:
- Developed OSacc, a web-based tool for survival analysis.
- Integrated seven independent transcriptomic profiles and clinical data from TCGA and GEO databases for 259 ACC patients.
- Implemented Kaplan-Meier (KM) survival plots with hazard ratio (HR) and log-rank tests for prognostic gene evaluation.
Main Results:
- OSacc provides rapid and user-friendly survival analysis for Adrenocortical Carcinoma.
- The tool facilitates the assessment of prognostic value for selected genes.
- Utilized data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases.
Conclusions:
- OSacc is a valuable resource for translational cancer research in Adrenocortical Carcinoma.
- The tool enhances the ability to screen, develop, and validate prognostic biomarkers.
- OSacc is freely available online for researchers and clinicians.
More Related Videos
09:08Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
Published on: January 12, 2020
07:41Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
Related Concept Videos
Cancer Survival Analysis
Comparing the Survival Analysis of Two or More Groups
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...