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Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
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Cognition and addiction
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Antonio Verdejo-Garcia1, Gloria Garcia-Fernandez2, Geert Dom3

  • 1Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia.

Dialogues in Clinical Neuroscience
|November 22, 2019
PubMed
Summary
This summary is machine-generated.

Substance use disorders (SUDs) are linked to cognitive deficits in memory, attention, and decision-making. Targeted cognitive training and therapies show promise for improving cognition and reducing relapse in individuals with SUDs.

Keywords:
cognitioncognitive enhancercognitive remediationcognitive trainingdecision-makingsubstance-use disordertreatment outcome

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Substance-use disorders (SUDs) are frequently associated with cognitive impairments.
  • These cognitive deficits can significantly impact an individual's daily functioning and treatment outcomes.
  • Understanding these deficits is crucial for developing effective interventions.

Purpose of the Study:

  • To review current knowledge on cognitive deficits in SUDs.
  • To examine the relationship between cognitive deficits and clinical outcomes, particularly relapse.
  • To explore potential cognitive training, remediation, and pharmacological interventions.

Main Methods:

  • Targeted literature review of studies on SUDs and cognitive function.
  • Analysis of research on cognitive training, remediation, and pharmacotherapies for SUDs.
  • Synthesis of findings to identify effective strategies and future research directions.

Main Results:

  • Individuals with SUDs exhibit moderate deficits in memory, attention, executive functions, and decision-making.
  • Impairments in executive functions and decision-making predict relapse.
  • Cognitive training, remediation, and pharmacotherapies show potential for cognitive recovery.

Conclusions:

  • Cognitive deficits are a significant feature of SUDs and predict relapse.
  • Interventions targeting cognitive biases, decision-making, memory, attention, and impulsivity hold promise.
  • Future research should focus on personalized, neuroscience-informed interventions for SUDs.