Related Experiment Video
Updated: Jan 3, 2026
07:26
Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel
Published on: June 29, 2015
18.5K
Understanding Infection-Induced Thrombosis: Lessons Learned From Animal Models
Nonantzin Beristain-Covarrubias1, Marisol Perez-Toledo2, Mark R Thomas1
1Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
Frontiers in Immunology
|November 22, 2019
Summary
Infection triggers thrombosis, a process called thrombo-inflammation, impacting patient outcomes. Understanding its mechanisms, particularly using Salmonella Typhimurium models, is key for developing targeted therapies.
Area of Science:
- Infectious disease
- Hematology
- Immunology
Background:
- Thrombosis is a common, poorly understood complication of infection, linked to adverse patient outcomes.
- Infection-associated thrombosis involves a strong inflammatory component, leading to platelet activation and thrombus formation (thrombo-inflammation).
- Mechanisms of infection-induced thrombosis and its role in host defense are unclear.
Purpose of the Study:
- To review the mechanisms of infection-associated thrombosis across various models.
- To highlight the utility of Salmonella Typhimurium infection as a model for studying thrombosis.
- To discuss therapeutic strategies for managing infection-induced thrombosis.
Main Methods:
- Review of existing literature on thrombosis in infection models.
- Focus on Salmonella Typhimurium infection models to analyze thrombosis at different stages and locations.
- Examination of thrombus composition and resolution dynamics.
Main Results:
- Salmonella Typhimurium models reveal organ-specific and time-dependent thrombosis patterns.
- Thrombi can persist for weeks in some sites while resolving within 24 hours in others.
- Thrombi induced by Salmonella Typhimurium are largely bacteria-free.
Conclusions:
- Salmonella Typhimurium infection provides valuable insights into infection-associated thrombosis.
- Understanding thrombosis timing and resolution is crucial for effective therapeutic interventions.
- Targeting infection-mediated thrombosis mechanisms can improve patient outcomes.
