Related Experiment Video

Updated: Jan 3, 2026

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

18.0K

Long Non-coding RNA LINC01787 Drives Breast Cancer Progression via Disrupting miR-125b Generation

Yongzhen Li1, Ying Song1, Zhihui Wang2

  • 1Department of Pathology, Xinxiang Medical University, Xinxiang, China.

Frontiers in Oncology
|November 22, 2019
PubMed

Insights

Researchers identified a new long noncoding RNA (lncRNA), LINC01787, that promotes breast cancer growth by blocking tumor-suppressing miR-125b. This lncRNA may serve as a prognostic biomarker and therapeutic target for breast cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer remains a leading cause of cancer-related deaths globally.
  • Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) are critical regulators in cancer.
  • miR-125b is a known tumor suppressor in breast cancer, but the role of lncRNAs is less understood.

Purpose of the Study:

  • To identify and characterize novel lncRNAs involved in breast cancer pathogenesis.
  • To elucidate the molecular mechanism of LINC01787 in breast cancer.
  • To evaluate LINC01787 as a potential biomarker and therapeutic target.

Main Methods:

  • Identification of LINC01787 in breast cancer tissues.
  • Investigation of LINC01787's interaction with pre-miR-125b and DICER.
  • Functional assays including cell proliferation, migration, and xenograft growth.
  • Correlation analysis of LINC01787 and miR-125b expression with clinical data.

Main Results:

  • LINC01787 was identified as a novel lncRNA that binds pre-miR-125b, inhibiting its processing by DICER and reducing mature miR-125b levels.
  • LINC01787 overexpression promoted breast cancer cell proliferation, migration, and tumor growth in vivo.
  • LINC01787 is upregulated in breast cancer tissues and associated with advanced stages and poor patient survival.
  • Inverse correlation observed between LINC01787 and miR-125b expression in breast cancer tissues.

Conclusions:

  • LINC01787 is an oncogenic lncRNA that promotes breast cancer by suppressing miR-125b maturation.
  • LINC01787 represents a potential prognostic biomarker and therapeutic target for breast cancer treatment.
Keywords:
breast cancerlong non-coding RNAmicroRNA generationpre-microRNAprogression

More Related Videos

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.0K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.7K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.4K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.7K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.8K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
13.1K
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
7.2K